Download E-books Systemic Lupus Erythematosus: Clinical and Experimental Aspects PDF

By Univ.-Doz. Dr. Josef S. Smolen, Univ.-Doz. Dr. Christoph C. Zielinski (auth.)

More than a hundred and forty years in the past, lupus erythematosus (LE) was once famous as a disorder entity by way of clinicians operating within the box of dermatology, which had just recently develop into an self sustaining clinical self-discipline. quickly after cutaneous lupus was once first pronounced, it used to be discovered that, except the outside, the sickness might contain different organs and hence be systemic in nature. The latter observations have been first made through MORITZ KApOSI [1], whose paintings has attracted renewed realization re­ cently and who succeeded FERDINAND VON HEBRA to the chair of dermatology on the clinical college in Vienna. The early description of lupus erythematosus in either its cutaneous and systemic manifes­ tations was once hence in detail linked to Vienna and its scientific tuition. the following part within the examine of lupus was once characterised by means of an in­ crease in wisdom of the kind and volume of organ involvement. The paintings through OSLER [2], LIBMANN and SACKS [3], and KLEMPERER [4] top represents those advances. the rise in medical wisdom of LE ultimately ended in DUBOIS' well-known monograph [5], which used to be pub­ lished at a time of renewed curiosity in SLE, elicited by way of the descrip­ tion through HARGRAVES et al. [6] of the LE-cell phenomenon. A extra unique research of this discovering published that the sickness was once charac­ terized via an irregular immune reaction, even though its pathogenetic implications have been nonetheless unclear.

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